Jiyong Lee Ph.D.

POSITIONS AND EMPLOYMENT

Assistant Professor (09/2019 – present)
Department of Chemistry and Biochemistry
The University of Texas at Tyler

Assistant Professor (07/2012 – 05/2019)
Department of Chemistry and Biochemistry
The University of Texas at Dallas

EDUCATION AND TRAINING

Post-doctoral Research Associate (09/2009 – 06/2012)

Department of Chemistry
The Scripps Research Institute
10550 N. Torrey Pines Road, La Jolla, CA 92037
Advisor: Jeffery W. Kelly, Ph.D.

Ph.D. in Biological Chemistry (2009)

University of Texas Southwestern Medical Center
5323 Harry Hines Boulevard, Dallas, TX 75390
Advisor: Thomas Kodadek, Ph.D. (currently at The Scripps Research Institute, Scripps Florida)
Thesis: Part I: Isolation of orexin receptor regulators via a microarray-based, two-color cell binding screen.
Part II: Targeted inactivation of protein triggered by visible light.

M.S. in Chemistry (2001)

Yonsei University
50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea
Advisor: Injae Shin, Ph.D.

B.S. in Chemistry (1999)

Yonsei University
50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Korea

PROFESSIONAL MEMBERSHIPS

American Chemical Society (01/2013 – present)
American Peptide Society (09/2016 – present)

ACHIEVEMENTS IN ORIGINAL INVESTIGATIONS

Publications

Independent publications

 

Castaneda, M., Chen, L, Zein, R., Lee, Y., Lim H-S., Lee, J. “A forkhead box protein C2 inhibitor: targeting epithelial-mesenchymal transition and cancer metastasis” ChemBioChem, 2018, 19, 1-7 (DOI: 10.1002/cbic.201800022). 

• Feature on the cover of ChemBioChem.

Chen, L., Long, C., Youn, J., Lee, J. “A phenotypic cell-binding screen identifies a novel compound targeting triple-negative breast cancer” ACS Combinatorial Science, 2018, 20 (6), 330-334 (DOI: 10.1021/acscombsci.8b00026).

Chen, L., Long, C., Tran, K. A. M., Lee, J. “A synthetic binder of breast cancer stem cells” Chemistry-A European Journal, 2018, 24 (15), 3694-3698 (DOI: 10.1002/chem.201705663).

This article has been highlighted in:

- EurekAlert!/AAAS: https://www.eurekalert.org/pub_releases/2018-02/uota-uds022218.php
- ScienceDaily: https://www.sciencedaily.com/releases/2018/02/180222162126.htm
- ChemistryViews: http://www.chemistryviews.org/details/ezine/10902474/Detect_Breast_Cancer_Stem_Cells_in_Vivo.html
- UT Dallas News Center: https://www.utdallas.edu/news/2018/2/22-32840_University-Scientists-Isolate-Cancer-Stem-Cells-Us_story-wide.html
- The Mercury: http://utdmercury.com/professor-research-team-isolate-stem-cells/

Chen, L., Long, C., Nguyen, J., Kumar, D., Lee, J. “Discovering alkylamide derivatives of bexarotene as new therapeutic agents against triple-negative breast cancer” Bioorg. Med. Chem. Lett., 2018, 28 (3), 420-424.

Veloria, J. R., Chen, L., Li, L., Breen, G. A. M., Lee, J., Goux, W. J. “Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells” MedChemComm, 2018, 9, 121-130.

Nguyen, J., Chen, L., Kumar, D., Lee, J. “Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line” Bioorg. Med. Chem. Lett., 2016, 26(19), 4753-4756.

Chen, Z., Li, N., Chen, L., Lee, J., Gassensmith, J.J. “Dual functionalized bacteriophage Qβ as a photocaged drug carrier” Small, 2016, 12(33), 4563-4571.

Previous Publications

Palhano, F. L., Lee, J., Grimster, N. P., Kelly, J. W. “Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils” J. Am. Chem. Soc., 2013, 135, 7503-7510.

Lee, J., Culyba, E. K., Powers, E. T., Kelly, J. W. “Amyloid-β forms fibrils by nucleated conformational conversion of oligomers” Nature Chemical Biology, 2011, 7, 602-609.

Lee, J., Udugamasooriya, D. G., Lim, H-S., Kodadek, T. “Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates” Nature Chemical Biology, 2010, 6(4), 258-260.

Lee, J., Reddy, M. M., Kodadek, T. “Discovery of an orexin receptor positive potentiator” Chemical Science, 2010, 1(1), 48-54.

Jung, H. J., Shim, J. S., Lee, J., Song, Y. M., Park, K. C., Choi, S. H., Kim, N. D., Yoon, J. H., Mungai, P. T., Schumacker, P. T., Kwon, H. J. “Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing” J. Biol. Chem. 2010, 285(15), 11584-11595.

Gocke, A. R., Archer, C. T., Udugamasooriya, D. G., Lee, J., Kodadek, T. “Isolation of antagonists of antigen-specific autoimmune T cell proliferation” Chemistry & Biology, 2009, 16(11), 1133-1139.

Lee, J., Yu, P., Xiao, X., Kodadek, T. “A general system for evaluating the efficiency of chromophoreassisted light inactivation (CALI) of proteins reveals Ru(II) tris-bipyridyl as an unusually efficient warhead” Molecular BioSystems. 2008, 4, 59-65.

Shim, J. S., Park, H. M., Lee, J., Kwon, H. J. “Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition” Biochem. Biophys. Res. Commun. 2008, 371(1), 99-103

Shim, J. S., Lee, J., Kim, K. N., Kwon, H. J. “Development of a new Ca2+/calmodulin antagonist and its anti-proliferative activity against colorectal cancer cells” Biochem. Biophys. Res. Commun. 2007, 359(3), 747-751.

Kim, D. H.*, Lee, J.*, Kwon. H. J. “Anti-tumor activity of N-hydroxy-7-(2-naphthylthio)heptanomide, a novel histone deacetylase inhibitor” Biochem. Biophys. Res. Commun. 2007, 356(1), 233-238. * equal contribution

Lee, J., Shim, J. S., Jung, S-A., Lee, S-T., Kwon, H. J. “N-Hydroxy-2-(naphthalene-2-ylsulfanyl)- acetamide, a novel hydroxamate inhibitor of aminopeptidase N and its anti-angiogenic activity” Bioorg. Med. Chem. Lett. 2005, 15(1), 181-183.

Yoo, H., Kim, S. H., Lee, J., Kim H. J., Seo, S. H., Chung, B. Y., Jin, C., Lee, Y. S. “Synthesis and antioxidant activity of 3-methoxyflavones” Bull. Kor. Chem. Soc. 2005, 26(12), 2057-2060

Kim, K. N., Lee, J., Kim, D. H., Yoo, J-S., Kwon, H. J. “A new synthetic analogue of thymidine, 7-(3- bromo-phenoxy)-tymidine, inhibits the proliferation of tumor cells” Bioorg. Med. Chem. Lett. 2005, 15(1), 77-79.

Shim, J. S., Lee, J., Park, H-J., Park, S-J., Kwon, H. J. “A new curcumin derivatives, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function” Chemistry & Biology 2004, 11, 1455-1463.

Shim, J. S., Kim, J. H., Lee, J., Kim, S. N., Kwon, H. J. “Anti-angiogenic activity of the homoisoflavanone from Cremastra appendiculata” Planta Medica 2004, 70(2), 171-173.

Cho, M-K., Kim, S-S., Lee, M. R., Shin, J., Lee, J., Lim, S-K., Baik, J-H., Yoon, C-J., Shin, I., Lee, W. “NMR studies on turn mimetic analogs derived from melanocyte stimulating hormones” J. Biochem. Mol. Biol. 2003, 36, 552-557.

Lee, M. R., Lee, J., Baek, B-H., Shin, I. “The first solid-phase synthesis of oligomeric a-aminooxy peptides” Synlett 2003, 3, 325.

Dok-Go, H., Lee, K. H., Kim, H. J., Lee, E. H., Lee, J., Song, Y. S., Lee, Y., Jin, C., Lee, Y. S., Cho, J. “Neuroprotective effects of antioxidative flavonoids, quercetin, (+)-dihydroquercetin and quercetin 3- methyl ether, isolated from opuntia ficus-indica var saboten” Brain Research 2002, 965, 130-136

Lee, M. R., Lee, J., Shin, I. “Synthesis of novel glycopeptidomimetics containing O- and N-glycosylated a-aminooxy acids by fragment coupling on solid support” Synlett 2002, No.9, 1463.

Shin, I., Lee, M, R., Lee, J., Jung, M., Lee, W., Yoon, J. “Synthesis of optically active phthaloyl Daminooxy acids from L-amino acids or L-hydroxy acids as building blocks for the preparation of aminooxy peptides” J. Org. Chem. 2000, 65(22), 7667-7675.

Shin, I., Lee, J. “Facile synthesis of N-and O-glycosylated a-aminooxy acids as building blocks for the structural studies of glycosylated pseudopeptides” Synlett 2000, No.9, 1297-1299.

Patents

Kwon, H. J., Shim, J. S., Lee, J. “A novel calmodulin antagonist and an immunosuppressive agent comprising thereof” Korea patent registration No: 100604697. Registration date: Jul. 19th, 2006.

Kwon, H. J., Kim, D. H., Lee, J. “A novel histone deacetylase inhibitor and method for preparing thereof” Korean patent registration No: 100620488. Registration date: Aug. 29th, 2008.

Kwon, H. J., Lee, J., Shim, J. S. “A novel aminopeptidase N inhibitor” Korea patent registration No: 100641076. Registration date: Oct. 25th, 2006.

Kwon, H. J., Shim, J. S., Lee, J. “Pharmaceutical composition for treating or preventing uncontrolled angiogenesis-related diseases comprising homoisoflavanone derivatives” Korea patent registration No:100510874. Registration date: Mar. 25th, 2003.

Patent applications

Lee, J., Chen, L., Long, C. “Synthetic binders of breast cancer stem cells” U.S. Provisional Patent Appl. 62/615,348 (filed on January 9, 2018)
• The following three life science/pharmaceutical companies have shown their interest in licensing this technology; currently negotiating a non-disclosure agreement (NDA) for further discussion.

1) Systems Oncology
2) BD Biosciences
3) MilliporeSigma

Lee, J., Castaneda, M. “FOXC2 inhibitor and methods of use thereof” U.S. Provisional Patent Appl. 62/647,317 (filed on March 23, 2018)
• Currently negotiating a non-disclosure agreement (NDA) with Systems Oncology for further discussion.

Lee, J., Chen, L. “Theranostic agent of triple-negative breast cancer” U.S. Provisional Patent Appl. 62/663,824 (filed on April 27, 2018)
• Currently negotiating a non-disclosure agreement (NDA) with Systems Oncology for further discussion.

Inventions disclosed to the Office of Technology Commercialization of UT Dallas

Lee, J., Chen, L., Long, C. “Synthetic binders of breast cancer stem cells” (Tech ID: 17050)

Lee, J., Chen, L. “Theranostic agent of triple-negative breast cancer” (Tech ID: 18004)

Lee, J., Castaneda, M. “Small molecule inhibitors of forkhead box protein C2 (FOXC2)” (Tech ID:18026)

Du, H., Lee, J. “A synthetic peptide-mimetic drug rescues mitochondrial F1Fo ATP synthase by targeting OSCP in Alzheimer’s disease-related conditions” (Tech ID: 18042).

Invited talks

Lee, J. “Identification of therapeutic targets on cancer stem cells” 2014 70th American Chemical Society Southwestern Regional Meeting, Fort Worth (TX), 11/19/2014

Lee, J. “Chemical biology technologies to identify small-molecule modulators of cancer stem cell” Department of Chemistry, Southern Methodist University, Dallas (TX), 04/24/2015.

Lee, J. “Identification of small molecule modulators of triple-negative breast cancer” Hamon Center for Therapeutic Oncology Research & Simmons Cancer Center Experimental Therapeutic Program, UT Southwestern Medical Center, Dallas (TX), 08/06/2015.

Lee, J. “Chemical biology technologies to identify small-molecule regulators of cancer stem cells” Division of Biochemical Technology, 249th American Chemical Society National Conference, Denver (CO), 03/22/2015 – 03/26/2015.

Lee, J. “Identification of small-molecule modulators of breast cancer stem cells” Department of Chemistry, Texas Christian University, Fort Worth (TX), 10/27/15

Lee, J. “Identification of small molecule modulators of cancer stem cells via phenotype-specific cell binding screening with combinatorial chemical library” The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015), Honolulu (HI), 12/15/2015 – 12/20/2015.

Lee, J. “Identification of small molecule modulators of cancer stem cells via phenotype-specific cell binding screening with combinatorial chemical library” Department of Chemistry and Biochemistry, Arlington (TX), 02/05/2016

Lee, J. “Identification of small molecule modulator of breast cancer stem cells”, Department of Chemistry and Biochemistry, Texas State University, San Marcos (TX), 04/04/2016

Lee, J. “Small molecule modulators of breast cancer stem cells” 2016 US-Korea Conference, Dallas (TX), 08/10/2016 – 08/13/2016.

Lee, J. “Novel chemical biology approaches to cancer therapeutics” ACS DFW 4th Young Investigator Meeting, Dallas (TX), 01/28/2017.

Lee, J. “Novel theranostic agent targeting triple-negative breast cancer” Department of Chemistry and Biochemistry, University of Tulsa, Tulsa (OK), 10/16/2017.

Lee, J. “Phenotypic cell-binding screens for chemical probe discovery” Department of Chemistry, University of North Texas, Denton (TX), 10/20/2017.

Meeting organized

Lee, J. (organizer & chair) “Chemical Probes” 2014 70th American Chemical Society Southwestern Regional Meeting, Fort Worth (TX), 11/19/2014

Poster presentations by mentored students and postdocs

Castaneda, M., Lee, J. “Discovery of a small molecule inhibitor of transcription factor FOXC2” American Chemical Society Dallas Fort Worth 48th Annual Meeting-in-Miniature, Dallas (TX), 04/25/2015.

Nguyen, J., Lee, J. “Development of autophagy-inducing small molecules for the treatment of cancer” American Chemical Society Dallas Fort Worth 48th Annual Meeting-in-Miniature, Dallas (TX), 04/25/2015.

Castaneda, M., Chen, L., Lee, J. “Targeting the epithelial-mesenchymal transition through the discovery of a small molecule inhibitor of FOXC2” 2016 SACNAS: National Diversity in Stem Conference, Long Beach (CA), 10/13 – 10/15, 2015.

Chen, L., Long, C., Lee, J. “Identification of small molecular compounds targeting breast cancer stem cells subpopulation via combinatorial chemical library screening” 2016 Keystone Symposia: Stem cells and Cancer, Breckenridge (CO), 03/06 – 03/10, 2016

Long, C., Chen, L., Lee, J. “Identification of selective ligands targeting breast cancer stem cells by using combinatorial chemical library” 35th American Chemical Society National Medicinal Chemistry Symposium, Chicago (IL), 06/26 – 06/29, 2016

Castaneda, M., Chen, L., Lee, J. “Targeting the epithelial-mesenchymal transition through the discovery of a small molecule inhibitor of FOXC2” ACS DFW 4th Young Investigators Meeting, Dallas (TX), 01/28/2017

Chen, L., Long, Ch., Tran, K. A., Lee, J. “Synthetic small molecule targeting CD24-/CD44+/ALDH+ cell population inhibits cancer stem cell activities in breast cancer” 2017 American Association for Cancer Research (AACR) Annual Meeting, Washington (DC), 04/01 – 04/05, 2017

Grant awarded

“Identification of Therapeutic Targets on Breast Cancer Stem Cells”
Jiyong Lee (PI)
Cancer Prevention Research Institute of Texas (CPRIT)
06/01/2015 – 07/31/2017

TEACHING AND MENTORING

Courses Taught

Biochemistry I (undergraduate course; F2012, F2013, F2014, F2015, Su2015, F2016, F2017)
General Chemistry II (undergraduate course; S2013)
Introductory Organic Chemistry I (undergraduate course; S2014, S2015, S2017, S2018, F2018)
Physical Biochemistry (graduate course; S2016, F2018)

Mentoring Activities

Graduate student advising for independent research
The graduate students have successfully made progress in their research projects and have been recognized
for their achievements.

Ph.D. Students advised: Catherine Aldrich, Chao Long, Maria Castaneda*, Jonghae Youn
*Maria Castaneda has joined my lab in 2014 and won a NSF Graduate Research Fellowship in 2016. I have
also mentored her to found a local chapter of Society for the Advancement of Chicanos/Latinos and Native
Americans in Science (SACNAS) at UT Dallas in 2017.

Undergraduate student advising for independent research
The lab experience has been proven to play important roles in reinforcing what the undergraduate students
learn in classrooms.

Undergraduate students advised: Catherine Isra, Tony Paul, Reema Palankar, Sarah Faheem, Daniel Kim,
Christine Truong, Joseph Younis, Triet Vincent Tran, Carolyn Nguyen, Kha Andy Tran**, Jennifer
Nguyen**, Alex Chu, Joon Yong Moon, Sara Al Dogom, Angela Yu, Ruba Zein, Tommy Tan, Madysen
Maynard, Jihyun Oh, Samuel Sung Chang, Peter Insung Kim
**Andy and Jennifer received UT Dallas undergraduate research award).