Assistant Professor
Department: Cellular and Molecular Biology
Shabbir Ansari
Dr. Shabbir A. Ansari is an Assistant Professor at the University of Texas at Tyler School of Medicine, where he leads a research program focused on the molecular regulation of hemostasis and thrombosis. His research centers on tissue factor (TF), the primary initiator of the extrinsic coagulation cascade, and examines how pathological stimuli, including inflammation, infection, malignancy, and cellular stress, drive dysregulated coagulation and thromboinflammatory disease.
Dr. Ansari received his Ph.D. in Hemostasis and Thrombosis through joint training at the University of Calcutta and the University of Texas Health Science Center at Tyler. He completed his initial postdoctoral training at UT Health Science Center at Tyler, followed by postdoctoral and instructor training at Harvard Medical School.
The Ansari lab focuses on defining posttranslational and epigenetic mechanisms that regulate TF expression and activity across diverse disease states. A central idea of the lab’s research is that thrombotic stimuli can induce persistent alterations in gene regulatory programs within vascular and immune cells, thereby modulating subsequent procoagulant responses. The lab investigates how these regulatory states are established, maintained, and functionally linked to thrombotic susceptibility and recurrence.
To address these questions, the lab employs integrated approaches combining epigenetic profiling, next-generation sequencing (e.g., ATAC-seq, RNA-seq), and mechanistic biochemical assays. These studies utilize primary human endothelial and myeloid cell systems alongside in vivo murine models of thrombosis to define cell-type–specific regulatory pathways. Through this multidisciplinary framework, the Ansari lab aims to uncover novel chromatin-based and post-translational mechanisms and identify therapeutic strategies beyond traditional anticoagulation.
Education and Training
Postdoctoral Fellowship: Harvard Medical School
Postdoctoral Fellowship: University of Texas at Tyler Health Science Center
PhD; Hemostasis and Thrombosis/ Biotechnology: University of Calcutta
Academic Appointments
Assistant Professor: University of Texas at Tyler School of Medicine
Instructor of Medicine: Harvard Medical School
Research Interests:
Molecular regulation of Tissue factor and immunothrombosis
Epigenetic and posttranslational regulation of hemostasis and thrombosis
Thrombotic disease and recurrent thrombosis
Host-pathogen interactions in coagulopathy
Cancer-associated thrombosis