UT Tyler School of Medicine Professor Published in Science and New England Journal of Medicine

July 9, 2025 | Elizabeth Wingfield

Dr. Pamela J. McShane, a professor in the Department of Pulmonology at The University of Texas at Tyler School of Medicine, co-authored a multi-center study titled “Phase 3 Trial of the DPP-1 Inhibitor, Brensocatib, in Bronchiectasis” that was published in Science and the New England Journal of Medicine.

“Few of us are ever published in Science or NEJM in our lifetimes, and advances in bronchiectasis are and have been extremely rare,” said Dr. Richard J. Wallace, director of the Mycobacteria/Nocardia Clinical Reference Laboratory. “This is such an honor for us at the program, and I want to congratulate Dr. McShane on her dedication, hard work and collaborative skills.”

McShane’s research focuses on treatment options for patients with bronchiectasis, a chronic, incurable lung disease that causes repeated lung infections and can lead to decline in lung function and hospitalizations. If the drug is approved, it will be the first FDA-approved drug for bronchiectasis, leading to preserved lung function and improved quality of life for patients.

McShane completed a fellowship training in pulmonary disease and critical care medicine at the University of Chicago. She is board certified by the American Board of Internal Medicine for pulmonary disease. During her time at the UT Tyler Health Science Center, she has served as the principal investigator in approximately a dozen clinical trials, treated countless patients impacted by bronchiectasis and has been instrumental in expanding the scope of clinical research for bronchiectasis.

With a mission to improve educational and health care outcomes for East Texas and beyond, UT Tyler offers more than 90 undergraduate and graduate programs to more than 10,000 students. Through its alignment with UT Tyler Health Science Center and UT Health East Texas, UT Tyler has unified these entities to serve Texas with quality education, cutting-edge research and excellent patient care. Classified by Carnegie as a doctoral research institution and by U.S. News & World Report as a national university, UT Tyler has campuses in Tyler, Longview, Palestine and Houston.