Aryal Lab
Laboratory Activities and News
Spring 2022
Undergraduate student Aayan Khan presented poster at Lyceum symposium. Khan A, Sulthana S, Kattel P, Pearson D. Deba F, Aryal S. Devising Bacterial Derived Extracellular Vesicle for Cancer Therapy. Lyceum, University of Texas at Tyler, 22nd April 2022.
Undergraduate student Prabhat Kattel present oral presentation at Lyceum symposium. Kattel P, Sulthana S, Trousil J, Pearson D, Aryal S. Synthesis and Characterization of Polymeric Nanoparticles: Effect of Nanoparticle Density in Cellular Compatibility and Uptake. Lyceum, University of Texas at Tyler, 22nd April 2022.
Fall 2021
NIH Award: Congratulations to Dr. Aryal (co-Investigator) and Dr. Zhoumeng Lin (Principal Investigator, University of Florida) NIH-RO1 award. Development of a web-based predictive model of nanoparticle delivery to tumors by integrating physiologically-based pharmacokinetic modeling with artificial intelligence.
Dr. Aryal gave an invited talk on “Engineering cell-based magnetic resonance imaging contrast agents”. 37th annual southern biomedical engineering conference. 2021 December 3-5, New Orleans, LA, USA.
Dr. Aryal gave an invited talk on “Engineering extracellular vesicles as a magnetic contrast agent”. Nanomedicine, Nanomaterials, and Nnotechnology, Vebleo Webinar. 2021June 25-28.
May-2021
17th May 2021 Dr. Aryal Joined Department of Pharmaceutical Sciences and Health Outcome, University of Texas at Tyler as an Associate Professor.
January-2021
Congratulations Sagar for successfully defending a Ph.D. thesis entitled "Engineering synthetic and natural vesicular system for tumor-targeted drug delivery". A bright future is waiting for you :)
September-2020
NIH Award: Congratulations to Dr. Aryal, collaborators, and group members for the recent NIH-NIBIB-R15 award. Re-engineering tumor cell-derived extracellular vesicles with exogenous tags for downstream analysis
Congratulations Ramesh for successfully defending a Ph.D. thesis entitled "Design Strategies and Application of Stimuli-Responsive Nanoparticles for Cancer Diagnosis and Therapy". A bright future is waiting for you :)
August-2020
Ramesh received Tina Mazza-Pipitone DARE to DREAM SCHOLARSHIP from Dean’s Office, Kansas State University. Congratulations Ramesh
May-2020
NSF Award: Congratulations to Dr. Aryal, collaborators, and group members for the recent collaborative NSF-RAPID award.
Congratulations Cesar for successfully completing Undergraduate degree with Chemistry major. A bright future is waiting for you :)
Ramesh's paper on "Synthesis and characterization of a tumor-seeking Lyp-1 peptide integrated lipid-polymer composite nanoparticle" was accepted for publication in Materials Advances. Congratulations Ramesh and the team!
Congratulations Sagar for successfully passing his Research Proposition Oral Examination (PropOral). He now becomes Ph.D. Candidate.
Sagar received Graduate research award from the Department of Chemistry. Congratulations Sagar!
Sagar's paper is featured in K state Today: "K-State researcher develops cell-based MRI contrast agent for efficient cancer diagnosis". Read more.
April-2020
Our NK-cell biomimetic technology has been patented! Congratulations Dr. Aryal Lab! Read more about the patent.
Sagar's paper on "Strategic reconstruction of macrophage-derived extracellular vesicles as a magnetic resonance imaging contrast agent" was accepted for publication in Biomaterials Science. Congratulations Sagar and the team!
Sagar's review paper on "Surface functionalization strategies of extracellular vesicles" was accepted for publication in Journal of Materials Chemistry B. Congratulations Sagar and the team!
Ramesh and Sagar received Graduate Student Summer Stipend Award from Johnson Cancer Research Center- KSU, Manhattan, KS. Congratulations Ramesh and Sagar!
Feb-2020
Cesar is selected to participate in the Undergraduate Research Day at the Capitol. He is one of five K-state students that will have the honor of representing KSU. He will present on March 4, 2020. Congratulations Cesar!
Jan-2020
Tuyen's paper on "Erythrocyte membrane concealed paramagnetic polymeric nanoparticle for contrast-enhanced magnetic resonance imaging" was accepted for publication in Nanoscale. Congratulations Tuyen and the team!
Sagar's paper on "pH-responsive cationic liposome for endosomal escape mediated drug delivery" was accepted for publication in Colloids and Surfaces B: Biointerfaces. Congratulations Sagar and the team!
Dec-2019
Rebecca received undergraduate research presentation award at Undergraduate Research Symposium, Kansas State University.
Nov-2019
Our research work to make new and safer MRI contrast media is covered in the local news channel KSNT News. Read more.
Congratulations Cesar Aparicio for receiving Research Award from the Department of Chemistry.
Undergraduate students, Rebecca Sutcliffe and Layah Johnson-Talbert joined the lab. Welcome to the group Rebecca and Layah!
Oct-2019
Sagar gave a podium presentation on "Gadolinium Infused Paramagnetic Hybrid Immuno-extracellular Vesicles For Contrast-Enhanced Magnetic Resonance Imaging" BMES National Meeting, Philadelphia. Well done Sagar!
Anthony Moreno presented a poster on "Synthesis and characterization of Palbociclib loaded core-shell lipid-polymer hybrid anticancer nanoparticles", BMES National Meeting, Philadelphia. Well done Anthony!
Sep-2019
Ramesh participated in a two-day communicating science conference workshop ComSciCOn-AIP at the American Institute of Physics in College Park, MD.
Ramesh's paper is covered in the Advanced Science News- Making MRIs Safer. Read the story.
Aug-2019
Ramesh and Sagar presented posters in a Designing Molecule-Workshop and Symposium at the Department of Chemistry, Kansas State University, Manhattan, KS. Great job Ramesh and Sagar!
REU student Anthony Moreno presented a poster on "Anti-Cancer Effect of Palbociclib Loaded Polymer-Lipid Nanoparticles", REU Symposium, August 1, Kansas State University, Manhattan, KS. Well done Anthony!
July-2019
Ramesh’s paper on "Integration of gadolinium in nanostructure for contrast-enhanced magnetic resonance imaging" is accepted for publication in WIREs Nanomedicine & Nanobiotechnology. Congratulations Ramesh and the team!!
Sagar Rayamajhi got selected to participate in Midwest Retreat for Diversity in Chemistry at Luther College in Decorah, Iowa. Congratulations Sagar Rayamajhi!
June-2019
Congratulations Ramesh for receiving the ComSciCom-AIP fellowship jointly organized by national flagship Communicating Science Conference and American Institute of Physics in College Park, MD. This award is given to the selected students from North America to participate in the workshop.
May-2019
REU student Anthony Moreno joined the lab to conduct his summer research. Welcome to the group Anthony!
Congratulations Ramesh for successfully passing his Research Proposition Oral Examination (PropOral). He now becomes Ph.D. Candidate.
Sagar's first paper on "Macrophage-derived exosome-mimetic hybrid vesicles for tumor-targeted drug delivery" was accepted for publication in ACTA Biomaterialia. Congratulations Sagar and the team!!
April-2019
Dr. Aryal gave an invited talk on 'Rationally designed nanoparticles for targeted drug delivery" at the Department of Chemistry, Pittsburg State University, Pittsburg, Kansas.
Lab received University Small Research Grant (USRG) to study natural killer cell mimicking nanoparticle homing in the humanized mice model.
Tuyen received Ohno Award (Graduate Research award) from the Department of Chemistry. Congratulations Tuyen!
Ramesh received the Johnson Cancer Research Center Travel Award to attend conferences. Congratulations Ramesh!
Congratulations Ramesh for receiving Johnson Cancer Research Center Graduate Fellowship to support our cancer research. Great job Ramesh!
March-2019
Congratulations Sagar for receiving the First Place presentation award at GRAD Forum. Well done Sagar!
Congratulations Tuyen for her future postdoctoral position at MD Anderson Cancer Center. Tuyen will join Dr. Khandan Keyomarsi's lab at the Department of Experimental Oncology in August to continue her cancer research. Best wishes for your career.
Congratulations Tuyen for successfully defending Ph.D. thesis entitled "Engineering nanoparticles using chemical and biological approaches for tumor-targeted delivery". A bright future is waiting for you :). Read her full dissertation.
February-2019
Our collaborative research paper with Dr. Mark Weiss's research group on "Biodistribution of gadolinium- and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor-bearing mice" was accepted for publication in Theranostics. Congratulations Tuyen, Ramesh, Dr. Aryal and the team!
January-2019
Congratulations Ramesh for receiving ACS Travel Award to attain the upcoming ACS meeting in Orlando, Florida. What a great way to kick-start the semester!
December-2018
Tuyen's paper on "Biomimetic surface modification of discoidal polymeric particles" was accepted for publication in Nanomedicine: Nanotechnology, Biology and Medicine. Congratulations Tuyen and the team!
Dr. Pitchaimani and Tuyen 's paper on "Biomimetic Natural Killer Membrane Camouflaged Polymeric Nanoparticle for Targeted Bioimaging" was accepted for publication in Advanced Functional Materials. Congratulations Arun, Tuyen and the team!
October-2018
Dr. Aryal gave an invited talk on "Cell membrane camouflage therapeutic nanoparticles: A biomimetic design to fight against cancer" at the Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical College, Omaha, Nebraska.
September-2018
Tuyen 's podium presentation on "Cell Membrane Disguised Nanoparticle with Tumor Targeting Motifs" awarded 1st place at Annual Biopharmaceutical Research & Development Symposium, University of Nebraska Medical School, Nebraska, Lincoln. Congratulations Tuyen!
Ramesh presented a poster on "Tumor-associated macrophage-specific lipid-polymer hybrid nanoparticle" at Annual Biopharmaceutical Research & Development Symposium, University of Nebraska Medical School, Nebraska, Lincoln. Well done Ramesh!
Dr.Pitchaimani joined Istituto Italiano di Tecnologia, Center for Nanoscience and Technology, Italy as a Marie-Curie Research Fellow. Congratulations Arun!
August-2018
Sagar presented a poster on “Engineering immune cell-derived hybrid exosome for tumor-targeted drug delivery” at 256th ACS National Meeting, Boston. Well done Sagar!
July-2018
Sagar received A & S Student Research Travel Award and GSC Travel Award to present a poster of his research at 256th ACS National Meeting, Boston. Good job Sagar!
Tuyen received Scott Fateley Memorial Award from the Department of Chemistry – KSU, Manhattan, KS. Congratulations Tuyen!
May-2018
Ramesh’s paper on "Influence of Polyethylene Glycol Passivation on the Surface Plasmon Resonance Induced Photothermal Properties of Gold Nanorods" was accepted for publication in Nanoscale. Congratulations Ramesh and the team!
April-2018
Dr. Pitchaimani's paper on "Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy" was accepted for publication in Biomaterials. Congratulations Arun and the team!
Tuyen received Berschied and Derstadt Graduate Fellowship in Chemistry from the Department of Chemistry – KSU, Manhattan, KS. Congratulations Tuyen!
Tuyen received Graduate Student Summer Award from Johnson Cancer Research Center – KSU, Manhattan, KS. Congratulations Tuyen!
March-2018
Ramesh gave a podium presentation on "Influence of polyethylene glycol coatings in the photothermal properties of gold nanorods" at 255th ACS National Meeting and Exposition, New Orleans, LA. Well done Ramesh!
Tuyen gave a podium presentation on "Effect of particle distance in magnetic properties of superparamagnetic iron oxide nanoparticle and its application, in contrast, enhance magnetic resonance imaging" at 255th ACS National Meeting and Exposition, New Orleans, LA. Good job Tuyen!
Dr. Aryal gave Invited Talk on "Integration of bio-membrane in synthetic nanoparticle for diagnosis and therapy" at 255th ACS National Meeting and Exposition, New Orleans, LA.
February 2018
Tuyen and Ramesh received A & S Student Research Travel Award and Johnson Cancer Research Center Graduate Student Travel Award to give a talk at Spring ACS National Meeting. Way to go Tuyen and Ramesh!
December-2017
Graduate student Sagar Rayamajhi joined the lab. Welcome to the group Sagar!
Tuyen was awarded Science Communication Fellows from Sunset Zoo, Manhattan, KS. Good job Tuyen!
November-2017
Tuyen's paper on "Nano-confinement-driven enhanced magnetic relaxivity of SPIONs for targeted tumor bioimaging" was accepted for publication in Nanoscale. Congratulations Tuyen!
Ramesh presented a poster on "Gold nanorod assisted near-infrared photothermal therapy of melanoma cancer cells" in KSU Research and the State forum, Student Union, Kansas State University. Good job Ramesh!
October-2017
Ramesh presented the poster on "Surface functionalized gold nanorod" in the ACS Midwest Regional Meeting, Lawrence, KS. Good job Ramesh!
August-2017
Our collaboration work with Dr. Eshete on "Interaction of Immune System Protein with PEGylated and Un-PEGylated Polymeric Nanoparticles" was accepted for publication in Advances in Nanoparticles. Congratulations Tuyen and Dr. Aryal!
Spring-2017
Dr. Aryal awarded Instrument Award, Johnson Cancer Research Center, Kansas State University, Manhattan, KS. Seed award
Dr. Aryal awarded Innovative Research Award, Johnson Cancer Research Center, Kansas State University, Manhattan, KS. Seed award
May-2017
Dr. Pitchaimani's paper on "Impact of cell adhesion and migration on nanoparticle uptake and cellular toxicity" was accepted for publication in Toxicology in Vitro. Congratulations Arun!
Our collaboration work with Dr. DeLong on "Elucidating the RNA Nano−Bio Interface: Mechanisms of Anticancer Poly I:C RNA and Zinc Oxide Nanoparticle Interaction" was accepted for publication in The Journal of Physical Chemistry C. Congratulations Tuyen and Dr. Aryal!
April-2017
Dr. Pitchaimani's paper on "Gd3+ tethered gold nanorods for combined magnetic resonance imaging and photo-thermal therapy" was accepted for publication in the Journal of Biomedical Nanotechnology. Congratulations Arun!
February-2017
Tuyen received First place and People’s choice award at 3 minute thesis (3MT) competition – KSU, Manhattan, KS.
Tuyen was selected to represent K-State at Midwestern Association of Graduate Schools (MAGS) 3MT® Competition. Congratulations Tuyen!
December-2016
Graduate student Ramesh Marasini joined the lab. Welcome to the group Ramesh!
Our collaboration review paper on "A review on nanoparticle-based technologies for biodetoxification" was accepted for publication in Drug and chemical toxicology. Congratulations Tuyen and Dr. Aryal!
Dr. Aryal's paper on "Membrane Fusion-Mediated Gold Nanoplating of Red Blood Cell: A Bioengineered CT-Contrast Agent" was accepted for publication in ACS Biomaterials Science and Engineering. Congratulations Dr. Aryal, Tuyen and Arun!
October-2016
Dr. Aryal awarded K-state open access publishing fund (KOAPF) award, Kansas State University, Manhattan, KS.
Tuyen's paper on "Engineered Nanomedicine with Alendronic Acid Corona Improves Targeting to Osteosarcoma" was accepted for publication in Scientific Reports. Congratulations Tuyen!
August-2016
Tuyen's poster presentation on "Engineered nano-detoxifier for intracellular detoxification of doxorubicin" was awarded 1st place poster award at International Society for Biomedical Polymers and Polymeric Biomaterials, Iselin, New Jersey. Congratulations Tuyen!
Sekhar's poster presentation on "Synthesis and characterization of bisphosphonate functionalized poly(l-lactide) as a bone seeking agent" was awarded 3rd place poster award at International Society for Biomedical Polymers and Polymeric Biomaterials, Iselin, New Jersey. Congratulations Sekhar!
May-2016
Dr. Pitchaimani presented poster on "Gadolinium infused theranostic liposomes for anticancer therapy" at American Association of Pharmaceutical Scientists, Boston, Massachusetts. God job Arun!
April-2016
Dr. Aryal gave invited talk on "Polymeric nanomedicine for targeting bone microenvironment" at Polymer Society of Korea, Daejeon, South Korea.
Tuyen received Phi Lambda Upsilon – Alpha Epsilon Chapter Graduate Classroom Award from Department of Chemistry, KSU, Manhattan, KS. Congratulations Tuyen!
Spring-2016
Dr. Aryal awarded Spring Innovative Research Award, Johnson Cancer Research Center, Kansas State University, Manhattan, KS. Seed award
March-2016
Tuyen received Graduate Student Summer Award from Johnson Cancer Research Center – KSU, Manhattan, KS. Congratulations Tuyen!
Tuyen's oral presentation on "Bone microenvironment targeted magnetic nanomedicine" was awarded 1st place at K-State Graduate Research, Arts, and Discovery (GRAD) Forum, Kansas State University, Manhattan, Kansas. Congratulations Tuyen!
Dr. Pitchaimani's paper on "Design and characterization of gadolinium infused theranostic liposomes" was accepted for publication in RSC Advances. Congratulations Arun!
Tuyen's paper on "Engineered biomimetic nanoabsorbent for cellular detoxification of chemotherapeutics" was accepted for publication in RSC Advances. Congratulations Tuyen!
Feb-2016
Tuyen and Sekhar represented K-State to present their research at Capitol Graduate Research Summit, State Capitol Building, Topeka, Kansas. Good job Tuyen and Sekhar!
December-2015
Mukund presented poster on "Synthesis and characterization of biomimetic hydroxyapatite nanoconstruct using chemical gradient across lipid bilayer for subsequent modification of titanium implant" at MRS Fall Meeting, Boston, Massachusetts. Good job Mukund!
Tuyen presented poster on "Multifunctional theranostics nanomedicine for targeted treatment of metastatic breast cancer to bone" at MRS Fall Meeting, Boston, Massachusetts. Good job Tuyen!
November-2015
Mukund's paper on "Synthesis and Characterization of Biomimetic Hydroxyapatite Nanoconstruct Using Chemical Gradient across Lipid Bilayer" was accepted for publication in Applied Materials and Interfaces. Congratulations Munkund!
October-2015
Tuyen and Sekhar were selected to represent K-State resent their research at Capitol Graduate Research Summit, State Capitol Building, Topeka, Kansas
Tuyen's poster presentation on "Engineering biomimetic nanoabsorbent for detoxification of chemotherapeutics" was awarded Best Poster at Research and State Forum, Kansas State University, Manhattan, Kansas. Congratulations Tuyen!
Sekhar's poster presentation on "Bisphosphonate functionalized nanomedicine for targeting bone microenvironment" was awarded Best Poster at Research and State Forum, Kansas State University, Manhattan, Kansas. Congratulations Sekhar!
Fall-2015
Dr. Aryal awarded Fall Innovative Research Award, Johnson Cancer Research Center, Kansas State University, Manhattan, KS. Seed award
July-2015
Dr. Aryal's presentation on "Chemotherapy combined with photothermal therapy based on the confinement of gold nanoconstruct" was awarded 1st place at International Society for Biomedical Polymers and Polymeric Biomaterials, Orlando, Florida.
June-2015
Dr. Arunkumar Pitchaimani joined the lab as a postdoctoral fellow. Welcome to the group Arun!
Spring-2015
Dr. Aryal awarded Mentoring Award, Kansas State University, Manhattan, Kansas. Seed award
November-2014
Graduate student Tuyen Nguyen and Soma Sekhar Sriadibhatla joined the lab. Welcome to the group Tuyen and Sekhar!
September-2014
Mukund Bahadur Koirala joined the lab as a Research Assistant. Welcome to the group Mukund!
August-2014
Dr. Aryal joined K-State as Assistant Professor. Welcome to K-State.